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The so-called ‘proof-of-principle’ approach, whereby ultra-high NP concentrations are used to ensure cytotoxicity, is evaluated on the basis of two considerations; firstly, from a scientific perspective, the concentrations used are in no way related to the actual doses required which, in many instances, discourages further vital investigations.

Her research interests cover areas of nanotoxicology and the utilization of nanoparticles for regenerative purposes as well as their clinical applications.If there is sufficient thiamine present in the cell then the thiamine binds to the m RNAs for the enzymes that are required in the pathway and prevents their translation.If there is no thiamine present then there is no inhibition, and the enzymes required for the biosynthesis are produced.Recent investigations have revealed many other direct actions of EGCG that are independent from anti-oxidative mechanisms.In this review, we discuss these novel molecular mechanisms of action for EGCG.

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